In vitro human GI model to screen for drug candidates, nutraceuticals, food, etc.

Details

Project Title	In vitro human GI model to screen for drug candidates, nutraceuticals, food, etc.
Track Code	P3181
Short Description	McGill University is offering a unique service based on an in vitro human GI tract system. Dr. Satya Prakash’s laboratory is the only laboratory in North America equipped with the Simulator of Human Intestinal Microbial Ecosystem (SHIME) device
Abstract	None

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Posted Date	Jan 25, 2010 8:34 AM

Additional

Journal of Microencapsulation, 2005; 22(5), 539–547
Artificial Cells, Blood Substitutes, and Biotechnology, 2007, 35, 359–375
Journal of Biomedicine and Biotechnology, 2007, 7, 13684
Appl Microbiol Biotechnol., 2008, 81, 225–233

Background

SHIME was developed by ProDigest BVBA in Belgium (see www.prodigest.eu). McGill, Dr. Prakash and ProDigest are working in close collaboration to offer services to the pharmaceutical, biotechnology and food industry.

Advantages

Dynamic model to study physiochemical, enzymatic and microbial parameters in the GI track in controlled in vitro settings;.
Model allows studying the entire GI track: stomach, small intestine and colon;
Easy way to assess drug candidates, food or nutraceutical products solubility, degradation and absorption;
Unique model to study the impact of drug candidates on GI microbial community;
Unique model to evaluate efficacy of probiotic/symbiotic treatments;
Alternative approach to expensive animal and human studies

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In vitro human GI model to screen for drug candidates, nutraceuticals, food, etc.

Details

Additional

Background

Advantages