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Customizable Multi-Organ Biochip

Details

Project TitleCustomizable Multi-Organ Biochip
Track Code24072
Websitehttps://techtransfer.universityofcalifornia.edu/NCD/24072.html?utm_source=AUTMGTP&utm_medium=webpage&utm_term=ncdid_24072&utm_campaign=TechWebsites
Short DescriptionNone
Abstract

There is an urgent need in the pharmaceutical industry to effectively and efficiently screen potential drug compounds during early stages of investigation to assess both effectiveness and toxicity. With patient-specific human induced pluripotent stem (iPS) cells, UC Berkeley researchers have developed in vitro disease-specific model tissues and organs to be used for high content drug screening and patient-specific medicine. These model tissues have been generated by either differentiating pluripotent stem cells inside a cell culture system or by directly introducing pre-differentiated organ-specific cells into a cell culture system.

 

By mimicking the dimensions and cellular arrangement of minimal functional units of human organs, cell culture units consisting of model tissue incorporated into microfluidic systems have been developed for various organ types and are connected to form a multi-organ system fed by a common medium. Side effects and metabolite toxicity can then be detected and studied for drug-screening and further pharmaceutical applications.

 

 
Tagsartificial organs, tissue, lab on chip, cell culture, culture systems, organ on chip, point of care, health, research tools, screening, stem cell, therapeutics, screening assays
 
Posted DateAug 12, 2017 11:36 AM

Advantages

each cell type maintains individual functional level 

- design of the tissue outlet channel allows fast and dense loading of cells for ex situ analysis

- hybrid system capable of mechanical, electrical and computational measurements for offline analysis

Potential Applications


- multi-organ drug screening system for toxicology studies

- disease-specific model tissue generation for drug testing

Additional Information

Publication

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications  



Additional Technologies by these Inventors



Tech ID/UC Case

24072/2014-163-0



Related Cases

2014-163-0

Contact Information

Name : Terri Sale

Title :

Department :

Email : terri.sale@berkeley.edu

Phone : 510-643-4219

Address :

Principal Investigator

Name : Kevin Edward Healy

Department :



Name : Luke Lee

Department :



Name : Peter Loskill

Department :



Name : Anurag Mathur

Department :



Name : Pia Rodriguez Nunez

Department :

Intellectual Property